Vagus nerve neuro-metabolic control

We investigate the vagus nerve as a key interface for regulating metabolic function. It is grounded in preclinical animal electrophysiology, where vagal activity is recorded and manipulated under controlled conditions to understand how afferent and efferent pathways encode metabolic state. Experimental paradigms include electrical stimulation, sensory and chemical perturbations, and simultaneous physiological readouts to assess metabolic and neural responses. The work aims to identify how vagal signalling contributes to glucose regulation and systemic homeostasis under anaesthesia and freely-moving animals. These studies provide mechanistic foundations for neuromodulation strategies targeting disorders like epilepsy and diabetes.

Relevant publications

• Malpica-Morales, 2025, Machine Learning: Science and Technology. DOI: 10.1088/2632-2153/ae023f
• Güemes et al., 2023, Journal of Neural Engineering. DOI: 10.1088/1741-2552/acfdcd
• Güemes et al., 2020, Bioelectronic Medicine. DOI: 10.1186/s42234-020-00046-4 
• Güemes et al., 2019 IEEE International Symposium on Circuits and Systems Proceedings, DOI:10.1109/ISCAS.2019.8702535.
• Güemes et al., 2019, IEEE Journal of Biomedical and Health Informatics. DOI: 10.1109/JBHI.2019.2938305
• Güemes et al., 2019, Medical & Biological Engineering & Computing. DOI: 10.1007/s11517-019-01950-x 
• Güemes et al., 2018, Bioelectronic Medicine. DOI: 10.1186/s42234-018-0009-4